Cubs vs Reds: Imanaga Takes the Mound in Crucial Friday Night Matchup
The Chicago Cubs (88-65) head into Friday night’s showdown against the Cincinnati Reds (77-76) as -126 favorites, looking to build on their recent momentum. With Shota Imanaga taking the ball against Nick Lodolo, this matchup has all the makings of a classic National League Central battle.
Game Information
Date: Friday, September 19, 2025
Time: 6:40 p.m. ET
Location: Great American Ball Park, Cincinnati
TV Coverage: MLB Network, Fox Sports Ohio, Marquee Sports Network
Betting Lines: Cubs -126, Reds +105
Run Total: 8.5 runs
Spread: Cubs -1.5
Pitching Matchup: Two Quality Lefties
Shota Imanaga Brings Consistency for Chicago
Imanaga gets his 24th start of the season carrying a 9-7 record with a solid 3.29 ERA across 134⅔ innings. The Japanese left-hander has been exactly what the Cubs needed in their rotation – consistent innings and quality starts. With 110 strikeouts, he’s shown the ability to miss bats when needed.
At 9-7, Imanaga is one win away from double digits, which would cap off what’s been an impressive debut season in Major League Baseball. His ability to command the strike zone and keep hitters off balance makes him a reliable option in this crucial late-season matchup.
Nick Lodolo Counters for Cincinnati
The Reds counter with Nick Lodolo, who brings an 8-8 record into his 27th start. Lodolo has been a workhorse for Cincinnati this season, consistently taking the ball and giving his team a chance to win. His experience and familiarity with the Cubs lineup could prove valuable.
Both pitchers bring similar profiles – left-handed, capable of going deep into games, and reliable enough to anchor their respective rotations down the stretch.
Cubs Offensive Attack
Nico Hoerner Sets the Table
Nico Hoerner continues to be the Cubs’ most consistent hitter, leading the team with a .301 batting average. His ability to get on base and create opportunities for the power hitters behind him has been crucial to Chicago’s success this season.
Power Production Throughout the Lineup
Pete Crow-Armstrong has emerged as the Cubs’ home run leader with 29 dingers while driving in 90 runs and slugging .481. His development into a legitimate power threat gives Chicago another dimension in their lineup.
Ian Happ provides veteran leadership with 129 hits and a .344 on-base percentage, while Seiya Suzuki leads the team with 91 RBIs despite a .244 average. This Cubs offense ranks 7th in MLB with 743 runs scored and 205 home runs, showing they can generate offense in multiple ways.
Reds Looking to Play Spoiler
Elly De La Cruz Brings the Speed and Power
Cincinnati’s offense revolves around the dynamic Elly De La Cruz, who leads the team with 19 home runs and 82 RBIs. His combination of speed and power makes him a constant threat to change the game with one swing or stolen base.
Solid Supporting Cast
TJ Friedl contributes with a .257 average, 12 home runs, and 76 walks, showing good plate discipline. Spencer Steer (.240, 18 HRs) and Austin Hays (.269, 15 HRs) provide additional offensive weapons for the Reds.
The Reds’ 4.5 runs per game (13th in MLB) shows they can compete offensively, though they’ll need their best effort against Imanaga and the Cubs’ pitching staff.
Statistical Edge Goes to Chicago
The Cubs hold advantages in several key categories:
- Runs per game: Cubs 4.9 vs Reds 4.5
- Home runs: Cubs 205 vs Reds 153
- Team ERA: Cubs 3.80 (7th) vs Reds 3.95 (15th)
- Strikeouts per game: Cubs 7.8 vs Reds 8.7
Chicago’s ability to avoid strikeouts while generating more power gives them clear offensive advantages.
Betting Analysis and Trends
The Cubs have been money as favorites this season, going 70-40 (63.6%) when favored overall. When favored by odds similar to Friday’s -126, they’re even better at 58-31 (65.2%).
Cincinnati has struggled as underdogs, winning just 40 of 82 games (48.8%) in that role. When facing odds of +105 or worse, they’re 25-32.
The total has gone under more often for both teams this season, with Cubs games staying under 75 times and Reds games going under 93 times.
Injury Report
Cubs: Kyle Tucker (calf) and Miguel Amaya (ankle) remain on the 10-day IL, while Justin Steele and others are on longer-term injured reserve.
Reds: Cincinnati continues to deal with several pitching injuries on the 60-day IL, including Wade Miley and Brandon Williamson.
Neither team faces critical injuries that should significantly impact Friday’s outcome.
Game Prediction
Final Score: Cubs 5, Reds 3
Total: Under 8.5 runs
Imanaga’s consistency gives the Cubs the pitching edge in what should be a tighter, lower-scoring affair than some expect. Both teams have quality left-handed starters who should keep the opposing offenses in check early.
Chicago’s superior offensive numbers and better recent form as favorites make them the logical choice, even on the road. The Cubs’ ability to work counts and avoid strikeouts should help them manufacture runs against Lodolo.
With two quality starters and solid bullpens, this game projects to stay under the 8.5-run total. The Cubs should edge out a close victory to continue their solid September play and maintain their strong position heading into the final weeks of the regular season.